PRIME Lab @ UCSF

We demonstrated that the growth rate of geographic atrophy area is directly proportional to the lesion perimeter. Based on this finding, we proposed GA perimeter-adjusted growth rate (mm/yr). Reference: https://doi.org/10.1016/j.oret.2020.12.002

GA progresses faster in regions further from the foveal center. Reference: https://iovs.arvojournals.org/article.aspx?articleid=2760084

To quantify the variation in GA lesion growth rate, we utilized the euclidean distance map and quantified GA border expansion rate at each retinal eccentricity in the macula demonstrating a progressive in crease of GA border expansion rate as the retinal eccentricity increases. Reference: https://iovs.arvojournals.org/article.aspx?articleid=2778030

To account for the variations in GA growth rate in various locations and different GA configurations, we developed a pixel-based analysis framework. Reference: Manuscript under revision.

To study the long-term disease natural history, we developed a novel Bayesian entry time realignment (BETR) method that can reconstruct the decades-long disease natural history by synthesizing short-term data. By performing the BETR method to the AREDS data, we horizontally translated individual datasets to convert the X-axis from Time after enrollment to inferred time after disease onset.
Here, we can see that the square root of GA area in individual eyes increases linearly over approximately 30 years but at different progression rates. Reference: https://www.nature.com/articles/s41598-022-08919-1

By combining fundus autofluorescence, OCT, OCT-angiography, microperimetry, and adaptive optics scanning light ophthalmoscopy, we studied anatomic factors associated with local macular sensitivity. Reference: https://iovs.arvojournals.org/article.aspx?articleid=2810687